TY - JOUR T1 - THE SYNTHESIS AND EVALUATION OF NEW DERIVATIVES OF 2,4 DIAMINOPYRIMIDINES WITH MALE CONTRACEPTIVE ACTIVITY TT - JF - MJIRI JO - MJIRI VL - 13 IS - 1 UR - http://mjiri.iums.ac.ir/article-1-968-en.html Y1 - 1999 SP - 27 EP - 32 KW - 2 KW - 4-Diaminopyrimidines; Male contraception; Male reproduction; Spermatogenesis; Fertility N2 - The discovery of the antifertility activity of gossypol led scientists and researchers to the development of compounds with antifertility activity that can be used as male contraceptives. These studies resulted in discovery of the antifertility activity of several classes of compounds which have been reported in the literature. This article deals with the synthesis of four new analogues of pyrimethamine, the derivatives of 2, 4-diamino-5 (3,4-dichlorophenyl)-6-alkyloxymethyl pyrimidine (methyl ethyl, n-propyl, iso-propyl), and the results of experimental antifertility evaluation of these compounds on male rats, which revealed a significant decrease in motility, viability, ESR and DSP indices in treated animals M3 ER -