RT - Journal Article T1 - BRONCHODILATORY AND ANTICHOLINERGIC EFFECTS OF CARUM CARVI ON ISOLATED GUINEA PIG TRACHEAL CHAINS JF - MJIRI YR - 1999 JO - MJIRI VO - 12 IS - 4 UR - http://mjiri.iums.ac.ir/article-1-986-en.html SP - 345 EP - 351 K1 - Carum carvi K1 - bronchodilatory K1 - anticholinergic K1 - guinea pig. AB - Carum carvi (CC) is a grassy plant which is believed to have several therapeutic effects, including anti-asthmatic properties. We have therefore studied the bronchodilatory and anticholinergic effects of this plant. The bronchodilatory effects of the aqueous extract (AE), macerated extract (ME), essential oil (EO), and 4µM theophylline (T) in comparison with saline (S) were examined by their relaxant effects on precontracted [by 10 µM methacholine (M)] isolated tracheal chains of guinea pigs (n=1O). The anticholinergic effects of AE, ME, EO, and 5 nM atropine (A) were tested by comparing the cumulative Log concentration-response curves (LCRCs) of Minduced contraction of tracheal chains and the effective concentration of M causing 50% of maximum response (EC50) in the presence of AE, ME, EO, and A with that of S. Although the bronchodilatory effects of AE, ME, and EO were lower than that Of T (p LA eng UL http://mjiri.iums.ac.ir/article-1-986-en.html M3 ER -