RT - Journal Article T1 - INFLUENCE OF CCK RECEPTOR AGONIST AND ANTAGONISTS ON TOLERANCE INDUCED TO ANTIPENTYLENETETRAZOL ACTIVITY OF DIAZEPAM JF - MJIRI YR - 1999 JO - MJIRI VO - 12 IS - 4 UR - http://mjiri.iums.ac.ir/article-1-989-en.html SP - 365 EP - 369 K1 - CCK agents K1 - diazepam K1 - pentylenetetrazol anticonvulsion test K1 - mice. AB - In the present study, the effects of caerulein and CCK receptor antagonist< on tolerance to the anti-pentylenetetrazol activity of diazepam has been studied. Different doses of diazepam (20, 30, 35, 40 and 50 mg/kg) were administered intraperitoneally for a period of 6 days in order to induce tolerance to diazepam. 48 h after the last dose of diazepam, a test dose of diazepam was tested for antipentylenetetrazol activity. When animals were treated with caerulein or the CCK receptor antagonists MK -329 and L-365,260, only L-365,260 reversed the tolerance to diazepam. It may be concluded that CCK-B receptor mechanisms may interact with tolerance induced by diazepam. LA eng UL http://mjiri.iums.ac.ir/article-1-989-en.html M3 ER -