TY - JOUR T1 - INFLUENCE OF CCK RECEPTOR AGONIST AND ANTAGONISTS ON TOLERANCE INDUCED TO ANTIPENTYLENETETRAZOL ACTIVITY OF DIAZEPAM TT - JF - MJIRI JO - MJIRI VL - 12 IS - 4 UR - http://mjiri.iums.ac.ir/article-1-989-en.html Y1 - 1999 SP - 365 EP - 369 KW - CCK agents KW - diazepam KW - pentylenetetrazol anticonvulsion test KW - mice. N2 - In the present study, the effects of caerulein and CCK receptor antagonist< on tolerance to the anti-pentylenetetrazol activity of diazepam has been studied. Different doses of diazepam (20, 30, 35, 40 and 50 mg/kg) were administered intraperitoneally for a period of 6 days in order to induce tolerance to diazepam. 48 h after the last dose of diazepam, a test dose of diazepam was tested for antipentylenetetrazol activity. When animals were treated with caerulein or the CCK receptor antagonists MK -329 and L-365,260, only L-365,260 reversed the tolerance to diazepam. It may be concluded that CCK-B receptor mechanisms may interact with tolerance induced by diazepam. M3 ER -