TY - JOUR JF - MJIRI JO - Med J Islam Repub Iran VL - 12 IS - 3 PY - 1998 Y1 - 1998/11/01 TI - A CLINICAL TRIAL TO EVALUATE THE EFFICACY OF FLUVASTATIN AND LOVASTATIN IN COMPARISON WI TH PLACEBO IN HYPERCHOLESTEROLEMIC PATIENTS TT - N2 - In this study, the effect of lovastatin and fluvastatin was compared with placebo in patients with high levels of total cholesterol and low density lipoprotein cholesterol (LDL-C) on the plasma lipid profile. In a prospective single blind clinical trial with convenient sampling, 120 hypercholesterolemic men and women with Tcholesterol ≥220 mg/dL, LDL-C ≥ 160 mg/dL, and triglyceride ≤ 350 mg/dL were selected and divided into 3 groups randomly. The fust group took lovastatin, 20 mg daily, the second group fluvastatin, 40 mg daily, and the third group took a placebo, all for 12 weeks. Compared with placebo, drug therapy of hypercholesterolemia with either lovastatin or fluvastatin decreased total cholesterol and LDL-C levels significantly but had no effect on high density lipoprotein and triglyceride values. Decrease of total cholesterol and LD L-C levels by both drugs are similar after the first 6 weeks but lovastatin was more effective after the second 6 week period. SP - 229 EP - 233 AU - MORADMAND, S AU - NIAKAN, MR AU - FOULADKOU, F AU - SHAFIEE, A AD - From the Department of Pharmacy and Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. KW - Fluvastatin KW - Lovastatin KW - Hypercholesterolemia UR - http://mjiri.iums.ac.ir/article-1-1000-en.html ER -