TY - JOUR T1 - THE EFFECT OF GENETIC AL AND ENVIRONMENTAL FACTORS ON LIPIDS: A TWIN STUDY TT - JF - MJIRI JO - MJIRI VL - 12 IS - 1 UR - http://mjiri.iums.ac.ir/article-1-1038-en.html Y1 - 1998 SP - 5 EP - 9 KW - Polycystic ovary syndrome KW - androgens. lipids KW - twin study. N2 - To assess the relative contribution of genetic and environmental factors (particularly androgens) on circulating levels of lipid fractions, serum androgen and lipid fractions were measured in 34 pairs of female-female twins aged from 15- 45 years, some of whom were discordant for polycystic ovary syndrome (PCOS) diagnosed by ultrasound. Nineteen pairs were monozygotic twins (MZ) and 15 pairs were dizygotic twins (DZ). Five pairs of MZ and 6 pairs of DZ were discordant for scan-PC a. We measured serum concentrations of total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), triglycerides (TRIG), lipoprotein (a) [LP(a)], and apolipoprotein B (apo B). Also, testosterone (T), dehydroepiandrosterone sulphate (DHEAS), sex hormone binding globulin (SHBG) and 3a-androstanediol glucuronide (3a-diol G) levels were measured. Transabdominal ultrasound was performed. Serum levels of TC, HDL-C, TRIG, LP(a) and apo B in the twins with PCO were not significantly different from the levels in their matched co-twins with normal ovaries. There were no significant correlations between androgen-hormones including T, DHEAS and 3a-diol G with any of the lipid measurements. Body mass index (BMI) was positively correlated with TRIG, LP(a) (both p M3 ER -