%0 Journal Article %A AZARM, TALEB %T SALVAGE CHEMO THERAPY WITH CYCLOPHOSPHAMIDE, DOXORUBICIN, AND CISPLATIN (CAP) IN ADVANCED BREAST CANCER %J Medical Journal of the Islamic Republic Of Iran %V 8 %N 2 %U http://mjiri.iums.ac.ir/article-1-1382-en.html %R %D 1994 %K Breast cancer, combination chemotherapy, CAP regimen., %X Twenty-one patients with advanced breast cancer (7 premenopausal and 14 postmenopausal women) were treated with a combination of cyclophosphamide, doxorubicin, and cisplatin (CAP). The median age of the patients was 43 years (range 36-61). This therapy was repeated every 3 weeks. Nine patients (group 1) received CAP as primary therapy for metastatic breast cancer, and twelve patients (group 2) received CAP as a second-line therapeutic agent. Of the 12 (57%) patients who responded, six (29%) had complete response (CR). The median disease-free survival (DFS) was 8 months. The response rate was highest for metastases in the pleura (83%) and lymph nodes (81 %), followed by skin (64%), liver and breast (55%). The overall response rate was higher in previously untreated patients than in those previously treated (89% versus 33%, p %> http://mjiri.iums.ac.ir/article-1-1382-en.pdf %P 75-80 %& 75 %! Chemotherapy in Advanced Breast Cancer %9 Original Research %L A-10-298-585 %+ From the Division of Hematology /Medical Oncology. Seyyed-al Shohada Hospital, Isfahan University of Medical Sciences. Isfahan, Islamic Republic of Iran. %G eng %@ 1016-1430 %[ 1994