RT - Journal Article T1 - BINDING OF THE ANTITUMOR DRUG ADRIAMYCIN TO DNA-HISTONE COMPLEXES JF - MJIRI YR - 1993 JO - MJIRI VO - 6 IS - 4 UR - http://mjiri.iums.ac.ir/article-1-1472-en.html SP - 275 EP - 279 K1 - Anthracycline K1 - Chromation K1 - Histones K1 - Adriomycin AB - Isotherms of the binding of the anthracycIine antibiotic, adriamycin (adriblastin), to DNA histone complexes was studied by means of spectroscopic analysis. The results indicated that: (a) binding of adriamycin to histones reduced the interaction of histones with DNA, (b) binding of the drug to DNA did not change the binding affinity of histone to DNA and, (c) in the explored binding range of r LA eng UL http://mjiri.iums.ac.ir/article-1-1472-en.html M3 ER -