%0 Journal Article %A BAHREMAND, SHAHLA %A AGHIGHI, YAHYA %A OLOOMI YAZDI, ZOHREH %A MOAYERI, HESHMAT %A RAZAVI, LALEH %A NATEGHI, MANSOUR %T EVALUATION OF LABORATORY FINDINGS IN CHILDREN WITH WILSON'S DISEASE IN EMA M KHOMEINI HOSPITAL DURING 1994-2003 %J Medical Journal of the Islamic Republic Of Iran %V 18 %N 4 %U http://mjiri.iums.ac.ir/article-1-615-en.html %R %D 2005 %K Wilson\'s disease, laboratory findings, children., %X Wilson's disease is a rare but treatable condition with variable clinical presentations. Its diagnosis depends on a combination of clinical and laboratory findings. We evaluated the clinical and laboratory findings in children with Wilson's disease (WD). Twenty -seven children (4-14 years, 59.2 % male, 40.7% female) with confirmed WD were evaluated between 1994 and 2003 at Imam Khomeini Hospital. Seventeen patients (64%) presented with liver abnormalities, 3( 11 %) with neurological features, 3(11 %) with fulminant hepatic failure and 4(14%) were asymptomatic siblings of patients with WD. The presence of Kayser Fleischer rings, high urine copper excretion, low ceruloplasmin level, and elevated liver copper concentration were detected in 51.8%, 77.7%, 92.5% and 72.7% of patients respectively. We emphasize on clinical findings together with one or more laboratory findings as a diagnostic guide in WD and also recommend evaluation of serum ceruloplasmin level and 24 hour urine copper excretion particularly when liver biopsy may not be obtained. %> http://mjiri.iums.ac.ir/article-1-615-en.pdf %P 327-330 %& 327 %! Lab Findings in Children with Wilson's Disease %9 Original Research: Clinical Science %L A-10-298-74 %+ The Pediatric Gastroenterology Ward, Emam Khomeini Hospital, Tehran University of Medical Sciences %G eng %@ 1016-1430 %[ 2005