TY - JOUR T1 - CEREBRAL BLOOD FLOW REGULATION IN ANESTHETIZED MORPHINE DEPENDENT RATS: THE ROLE OF THE ADENOSINE SYSTEM TT - JF - MJIRI JO - MJIRI VL - 18 IS - 4 UR - http://mjiri.iums.ac.ir/article-1-619-en.html Y1 - 2005 SP - 353 EP - 359 KW - Cerebral blood flow; Morphine dependent rat. N2 - Adenosine has many of the characteristics of a regulator of cerebral blood flow and adenosine receptors change in morphine dependency. In this study the changes in adenosine receptors' responsiveness of pial vessels in the hind limb area of the sensory cortex were evaluated in morphine dependent rats (MDR) using the laser Doppler flowmetry technique. Adult male Sprague Dawley rats (250-350 g) were used in all experiments. Animals were made morphine dependent, thereafter local effects of adenosine receptor agonists and antagonists on regional cerebral blood flow ( rCBF) were investigated. Results obtained in this study show that adenosine (10-5, 10-4, 10-3M) increases rCBF in a dose dependent manner in sham operated, control and MD R, so that the increase of rCBF inMD R is statistically significant (p M3 ER -