TY - JOUR T1 - EFFECTS OF NOVEL 2-ALKYLAMINOSUBSTITUTED DIHYDROPYRIDINES ON RABBIT JEJUNUM TT - JF - MJIRI JO - MJIRI VL - 18 IS - 4 UR - http://mjiri.iums.ac.ir/article-1-620-en.html Y1 - 2005 SP - 361 EP - 364 KW - 2-Dimethylamino-substituted dihydropyridines KW - Rabbit jejunum KW - Calcium Channel. N2 - In order to investigate the effects of dimethylamino substituent at position 2 of the dihydropyridine nucleus on activity, starting from dialkyl l ,4-dihydro-2,6-dimethyl-4- (l-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyridinedicarboxylates (5a-f) which their synthesis and effects as calcium channel antagonist on guinea-pig ileum has been reported previously, dialkyl l,4-dihydro-2-[2-(dimethylamino)ethyl]-6-methyl-4-(l-benzyl-2- alkylthio-5-imidazolyl)-3,5-pyridinedicarboxylates (6a-f) were synthesized. Rabbit jejunum was used to determine the relaxant or antagonistic activity of the test compounds. The test compounds (6c-e) inhibited the spontaneous contractile activity dose-dependently and completely, while high-K+ contracted tissues were relaxed partially. M3 ER -