AU - Aghili, Rokhsareh AU - Honardoost, Maryam AU - Khamseh, Mohammad E TI - COVID-19: Case fatality and ACE2 inhibitors treatment concerns in patients with comorbidities PT - JOURNAL ARTICLE TA - MJIRI JN - MJIRI VO - 34 VI - 1 IP - 1 4099 - http://mjiri.iums.ac.ir/article-1-6799-en.html 4100 - http://mjiri.iums.ac.ir/article-1-6799-en.pdf SO - MJIRI 1 ABĀ  - The Corona Virus Disease 2019 (COVID-19) outbreak is becoming pandemic with the highest mortality in patients with associated comorbidities. These RNA viruses containing 4 structural proteins usually use spike protein to enter the host cell. Angiotensin-converting enzyme 2 (ACE2) acts as a host receptor for the virus. Therefore, medications acting on renin-angiotensin-aldosterone system can lead to serious complications, especially in patients with diabetes and hypertension. To avoid this, other potential treatment modalities should be used in COVID-19 patients with associated comorbidities. CP - IRAN IN - LG - eng PB - MJIRI PG - 1011 PT - Review Article YR - 2020