AU - AsghariHanjani, Nazanin AU - Vafa, Mohammadreza TI - The role of IGF-1 in obesity, cardiovascular disease, and cancer PT - JOURNAL ARTICLE TA - MJIRI JN - MJIRI VO - 33 VI - 1 IP - 1 4099 - http://mjiri.iums.ac.ir/article-1-4706-en.html 4100 - http://mjiri.iums.ac.ir/article-1-4706-en.pdf SO - MJIRI 1 ABĀ  - Background: Insulin-like growth factor1 (IGF1) is a polypeptide that structurally is similar to human pro-insulin, one of the factors that is altered in obesity and many related diseases, hence a large body of research devoted to evaluate it. Methods: In this mini-review, we briefly explain the role of IGF1 in different conditions, including obesity, cardiovascular disease, and cancer through the results of review and original articles in both animal and human studies. Results: The short-term metabolic effect of IGF-1 is insulin-like, and its long-term effect is growth factor-like. IGF1 has different roles in the initiation and progression of different diseases, because in some cases, the anti-apoptotic effect, can help cell survival while in others, it may lead to cancer or increment of adipocytes. Conclusion: It is highly recommended to consider the different impacts of IGF1 in health and diseases prevention in future studies and interventions. CP - IRAN IN - Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran LG - eng PB - MJIRI PG - 342 PT - Review Article YR - 2019