%0 Journal Article %A Pashazadeh, Mehrdad %T The role of tumor-isolated exosomes on suppression of immune reactions and cancer progression: A systematic review %J Medical Journal of the Islamic Republic Of Iran %V 34 %N 1 %U http://mjiri.iums.ac.ir/article-1-6199-en.html %R 10.47176/mjiri.34.91 %D 2020 %K Exosome, Cancer pathogenesis, Tumor, Metastasis, Immune system, %X Background: Exosomes are extracellular cells (EVs) emancipated by various cell types and are involved in cell-to-cell transmission. In cancer diseases, exosomes emerge as local and systemic cells to cell mediators of oncogenic information and play a significant role in the advancement of cancer through the horizontal transfer of various molecules, such as proteins and miRNAs. Methods: In this study, 66 articles from PubMed, MEDLINE, Science Direct, Cochrane, EMBASE, and Scopus were used as English sources. Results: The biological distribution of cancer cell-derived exosomes in tumor tissue is an important factor in detecting their role in tumor increase; on the other hand, a limited number of studies have examined the biodistribution of exosomes in tumor tissues. While exosomes function as cancer biomarkers and support cancer treatment, we have a long way to improve the antitumor treatment of exosomes and develop exosome-based cancer diagnostic and therapeutic strategies. Conclusion: This review describes the science and significance of cancer pathogenesis and exosomes relative to cancer treatment resistance. %> http://mjiri.iums.ac.ir/article-1-6199-en.pdf %P 639-645 %& 639 %! Role of exosomes in cancer progression %9 Systematic Review %L A-10-5449-1 %+ Immunology Division, Department of Microbiology, Health Science Institute, Bursa Uludag University & Department of Immunology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey %G eng %@ 1016-1430 %[ 2020