RT - Journal Article T1 - The role of tumor-isolated exosomes on suppression of immune reactions and cancer progression: A systematic review JF - MJIRI YR - 2020 JO - MJIRI VO - 34 IS - 1 UR - http://mjiri.iums.ac.ir/article-1-6199-en.html SP - 639 EP - 645 K1 - Exosome K1 - Cancer pathogenesis K1 - Tumor K1 - Metastasis K1 - Immune system AB - Background: Exosomes are extracellular cells (EVs) emancipated by various cell types and are involved in cell-to-cell transmission. In cancer diseases, exosomes emerge as local and systemic cells to cell mediators of oncogenic information and play a significant role in the advancement of cancer through the horizontal transfer of various molecules, such as proteins and miRNAs. Methods: In this study, 66 articles from PubMed, MEDLINE, Science Direct, Cochrane, EMBASE, and Scopus were used as English sources. Results: The biological distribution of cancer cell-derived exosomes in tumor tissue is an important factor in detecting their role in tumor increase; on the other hand, a limited number of studies have examined the biodistribution of exosomes in tumor tissues. While exosomes function as cancer biomarkers and support cancer treatment, we have a long way to improve the antitumor treatment of exosomes and develop exosome-based cancer diagnostic and therapeutic strategies. Conclusion: This review describes the science and significance of cancer pathogenesis and exosomes relative to cancer treatment resistance. LA eng UL http://mjiri.iums.ac.ir/article-1-6199-en.html M3 10.47176/mjiri.34.91 ER -