%0 Journal Article %A Hassanpour, Seyed Esmail %A Farnoush, Nazila %A Karami, Mohammad Yasin %A Makarem, Alireza %T The effect of silicone gel versus contractubex gel on the upper-extremity postsurgical scars: A randomized, double-blinded, controlled trial %J Medical Journal of the Islamic Republic Of Iran %V 34 %N 1 %U http://mjiri.iums.ac.ir/article-1-6248-en.html %R 10.47176/mjiri.34.146 %D 2020 %K Contractubex gel, Silicone gel, Hypertrophic scar, Upper-extremity, %X Background: Wound healing is a process that has three overlapping inflammatory, proliferative, and reconstruction phases. Silicone gel and Contractubex (onion extract gel) are two main topical agents used for the prevention and treatment of hypertrophic scars. This clinical trial study aimed to evaluate the efficacy and safety of onion extract and silicone gel on hypertrophic scars of the upper extremity and compare it to non-treated patients. Methods: This randomized, double-blind, parallel, clinical trial was done on 120 male patients who had undergone upper extremity sharp injury repair. Patients were assigned to three groups, i.e., Silicone gel (Kelo-cort™; WA, USA) (group 1; 40 patients), Onion extract (Contractubex™, Merz Pharma, Frankfurt, Germany) gel (group 2; 40 patients), and No Intervention (group 3; 40 patients), using drawing sealed envelopes and a computer-based table of randomization. Data were recorded using the Vancouver scale in each visit by two surgeons who were blinded to the study groups. IBM SPSS Statistics for Windows, Version 22.0. (Armonk, NY: IBM Corp). Data were compared using the ANOVA test. A P-value of less than 0.05 was considered statistically significant. Results: Vascularity (p=0.200), pliability (p=0.058), pigmentation (p=0.701), and height (p=0.438) as subjective scar parameters were approximately similar in post-upper extremity sharp injury wound hypertrophic scar among the three groups. Conclusion: Vascularity, pliability, pigmentation and height, as subjective scar parameters, were not statistically different in post-upper extremity sharp injury wound hypertrophic scar among the groups. Even though onion extract gel and Silicone gel show preventive effects in the literature, especially in burns wounds, further studies are recommended to be conducted to prove the topical effects of above-mentioned gels in patients. %> http://mjiri.iums.ac.ir/article-1-6248-en.pdf %P 1005-1010 %& 1005 %! Silicone gel and contractubex gel effect on the postsurgical scars %9 Original Research %L A-10-5450-2 %+ Department of Plastic Surgery,15 Khordad Educational Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran %G eng %@ 1016-1430 %[ 2020