Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1377
8
1
gregorian
1998
11
1
12
3
online
1
fulltext
en
A CLINICAL TRIAL TO EVALUATE THE EFFICACY OF FLUVASTATIN AND LOVASTATIN IN COMPARISON WI TH PLACEBO IN HYPERCHOLESTEROLEMIC PATIENTS
Pharmacology
Pharmacology
Original Research
Original Research
In this study, the effect of lovastatin and fluvastatin was compared with placebo
in patients with high levels of total cholesterol and low density lipoprotein cholesterol
(LDL-C) on the plasma lipid profile. In a prospective single blind clinical trial with
convenient sampling, 120 hypercholesterolemic men and women with Tcholesterol
≥220 mg/dL, LDL-C ≥ 160 mg/dL, and triglyceride ≤ 350 mg/dL were
selected and divided into 3 groups randomly. The fust group took lovastatin, 20 mg
daily, the second group fluvastatin, 40 mg daily, and the third group took a placebo,
all for 12 weeks. Compared with placebo, drug therapy of hypercholesterolemia with
either lovastatin or fluvastatin decreased total cholesterol and LDL-C levels
significantly but had no effect on high density lipoprotein and triglyceride values.
Decrease of total cholesterol and LD L-C levels by both drugs are similar after the first
6 weeks but lovastatin was more effective after the second 6 week period.
Fluvastatin, Lovastatin, Hypercholesterolemia
229
233
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-451&slc_lang=en&sid=1
S
MORADMAND
20031947532846004768
20031947532846004768
Yes
From the Department of Pharmacy and Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
MR
NIAKAN
20031947532846004769
20031947532846004769
No
F
FOULADKOU
20031947532846004770
20031947532846004770
No
A
SHAFIEE
20031947532846004771
20031947532846004771
No