Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1377
8
1
gregorian
1998
11
1
12
3
online
1
fulltext
en
EVALU ATION OF INSULIN-SUL FONYLUREA COMBINATION V ERSIJS INSULIN AL ONE IN THE T REATMENT OF NON-INSULIN D EPENDENT DIABETES MELLITU S (NID DM)
Pharmacology
Pharmacology
Original Research
Original Research
Lowering the glucose level in diabetic patients reduces the risk of many
consequences which are usually reported in these patients. Non-insulin dependent
(type II) diabetes which cannot be controlled with sulfonylureas alone can be
controlled with a combination of sulfonylurea and insulin. In an open randomized
trial 58 patients were divided into three groups. The fIrst group received only insulin
based on their blood glucose level. The second group received a set amount of insulin
plus the required amount of glibenclamide and the third group received a set amount
of insulin plus the required amount of chlorpropamide based on their glycemic
control. All three groups had a significant reduction of blood glucose, total cholesterol
and triglyceride levels. The best long term glycemic control was in the second group
with the lowest HbAlc(% ). In these patients bedtime insulin and daytime sulfonylurea
(B IDS) gives better glycemic control. This method of therapy is a valuable option for
patients with NIDDM whose hyperglycemia cannot be controlled by sulfonylureas
and do not have compliance with more than one injection a day.
235
239
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-452&slc_lang=en&sid=1
K
GHOLAMI
20031947532846004772
20031947532846004772
Yes
From the Department of Clinical Pharmacy, College of Pharmacy, Tehran University of Medical Sciences,Tehran, and the Department of Endocrinology, College of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran.
M
PAJOOHI
20031947532846004773
20031947532846004773
No
A
MALMIR
20031947532846004774
20031947532846004774
No
N
JAZAYERI
20031947532846004775
20031947532846004775
No