Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1377
8
1
gregorian
1998
11
1
12
3
online
1
fulltext
en
THE EFFECT OF BENZODIA ZEPINES ON THE STRESS-INDUCED RESPONSES OF THE NORA DRENERGIC A ND SEROTONERGIC PROJECTIONS TO THE RAT HIPPOCAMPUS
Physiology
Physiology
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
Microdialysis was used to measure the effect of benzodiazepines (BDZs) on
basal levels and on stress-induced increases of 5 -hydroxytryptamine (5 -HT), 5 -
hydroxyind oleacetic acid (5 -HIAA) , noradrenaline (NA), and
dihydroxyphenylacetic acid (DOP AC). The stressors used were a 5 min tail pinch
or a 10 min period of restraint. A subcutaneous injection of 5 mg/kg diazepam
decreased basal levels of 5 -HT, 5 -HIAA, and DOPAC, but not NA. There was no
effect on the stress-induced increase in 5 -HT, NA, and 5 -HIAA, while the increase
in DOPAC was completely abolished. Local infusion of 5 µM flurazepam
decteased the basal level of 5 - HT but not 5 -HIAA and abolished the stress-induced
increase of 5 -HIAA but not 5 -HT. These results suggest that the anxiolytic action
of BDZs is unlikely to be attributable to the suppression of stress-induced increases
in the release of NA or 5 -HT in the hippocampus.
Diazepam, Noradrenaline, Serotonin, Stress, Hippocampus, Microdialysis.
241
247
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-453&slc_lang=en&sid=1
A
VAHABZADEH
20031947532846004776
20031947532846004776
Yes
From the Department of Physiology, Iran University of Medical Sciences, Tehran, I.R. Iran
M
FILLENZ
20031947532846004777
20031947532846004777
No
the University Laboratory of Physiology, University of Oxford, Oxford, U.K.