Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1377
8
1
gregorian
1998
11
1
12
3
online
1
fulltext
en
CYTOKINE AND GROWTH FACTOR MODULATION OF CELL CYCLE EVENTS IN HUMAN MELANOMA CELL LINES
General
General
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
Cytokines influence cell cycle events, which in some but not all instances can
be associated with melanoma progression. Analysis of the G0/G 1 and S phase
fractions of the cell cycle was used to assay the proliferative or inhibitory activity
of cytokines against ten human melanoma cell lines, including pairs of cell lines
derived from primary and metastatic tissue of individual patients. Cytokines and
growth factors were generally capable of inducing either a proliferative or an
inhibitory effect, depending upon the melanoma cell line tested.
Distinct differences in responsiveness between the primary and metastatic
partners of related pairs of melanoma cell lines was observed for IL-l β, IL-6,
TNFα, TGFβ2, IFNα, IFNyand IGF-2. This data is complementary to previous
works1.2 showing IL-6 and TGFβ2 to be inhibitory to.cell lines derived from early,
but not advanced-stage melanomas. These alterations in cell cycle events were
coincidental with a reduced expression of lCAM-1 and/or MHC antigen expression
in response to some of these cytokines.
Primary and metastatic melanoma, cytokine, cell cycle, proliferative and inhibitory effect, flow cytometry.
249
257
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-454&slc_lang=en&sid=1
AR
ANDALIB
20031947532846004778
20031947532846004778
Yes
FromEsfahan Medical School, Esfahan,I.R. Iran
J
LAWRY
20031947532846004779
20031947532846004779
No
Sheffield University Medical School, UK
BJ
BURNS
20031947532846004780
20031947532846004780
No
Sheffield University Medical School, UK
AK
MURRAY
20031947532846004781
20031947532846004781
No
Sheffield University Medical School, UK
M
HERLYN
20031947532846004782
20031947532846004782
No
Wistar Institute, Philadelphia, USA.
RC
REES
20031947532846004783
20031947532846004783
No
Sheffield University Medical School, UK