Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1377
8
1
gregorian
1998
11
1
12
3
online
1
fulltext
en
COMPARISON BETWEEN THE EFFECTS OF 5 PERCENT HYPERTONIC SODIUM CHLORIDE SOLUTION AND 0.9 PERCENT SODIUM CHLORIDE SOLUTION ON LEFT VENTRICUL AR CONTRACTION
Anesthesia
Anesthesia
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
Hypertonic saline solution can absorb part of the intracellular fluid volume into
the extracellular space. The effects of this solution on the cardiovascular system are
increased coronary flow and increased left ventricular contraction, without sympathetic
system activation. This study was designed to assess the effects of hypertonic saline
solution in open heart surgery and to compare it with normal saline solution.
In a case control double-blind study, 46 patients (two groups of23 patients each)
were selected and treated with 2 different methods after open heart surgery. The
first group (case) received 5% hypertonic saline solution and the second group
(control) received 0.9 percent saline. Physical exam findings, left ventricular
pressure and urinary output were measured to compare the two groups.
2, 3, 5, 10 and 30 minutes after the injection of the solution, the indicators of the
study were measured. Left ventricular pressure and pulse rate were decreased and
mean arterial pressure was increased in the case group. Urinary output in the case
group was more than the control.
It therefore seems that hypertonic saline solution can increase cardiac contractility
without increasing sympathetic activity, and thus has positive inotropic effects. This
solution seems more useful regarding it's therapeutic effects in open heart surgery.
Hypertonic solution, Left ventricular pressure, Open heart surgery
291
293
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-460&slc_lang=en&sid=1
A
HEIDARPOUR
20031947532846004799
20031947532846004799
Yes
From the Department of Anesthesiology, Baghiatallah (a.s.) University of Medical Sciences, Tehran
K
BAGHERI
20031947532846004800
20031947532846004800
No
the Depariment of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran
H
AZARSINA
20031947532846004801
20031947532846004801
No
From the Department of Anesthesiology, Baghiatallah (a.s.) University of Medical Sciences, Tehran
A
BORDBAR
20031947532846004802
20031947532846004802
No
the Depariment of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran
N
FATEH
20031947532846004803
20031947532846004803
No
the Depariment of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran