Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1377
8
1
gregorian
1998
11
1
12
3
online
1
fulltext
en
SERIOUS ARRHYTHMIA INDUCED BY TERFENADINE-ERYTHROMYCIN INTERACTIONS
Pharmacology
Pharmacology
case report
case report
Since the introduction of our local manufacturing of terfenadine, we have
observed and expressed our concern about a small but increasing number of serious
ventricular arrhythmias associated with the use of this non sedating antihistamine.
In January 1997 a case of torsade de pointes ventricular tachycardia was detected
in a previously healthy woman taking terfenadine with erythromycin.
Electrocardiography revealed QT interval prolongation and QRS widening. One
hour after emergency room admission, her arrhythmia degenerated to ventricular
fibrillation and she died of cardiac arrest. Episodes of torsade de pointes are most
likely the result of the quinidine-like action of terfenadine. Dosage restriction and
awareness of the clinical conditions and drug interactions capable of inhibiting the
metabolism of terfenadine are essential for prevention of this serious reaction.
299
301
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-462&slc_lang=en&sid=1
MOJTABA
MOJTAHEDZADEH
20031947532846004806
20031947532846004806
Yes
From the Department of Pharmacotherapy (Clinical Pharmacy). Faculty of Pharmacy. Tehran University of Medical Sciences
ABBAS
MOHAGHEGHI
20031947532846004807
20031947532846004807
No
the Department of Cardiology. Faculty of Medicine. Tehran University of Medical Sciences. Tehran. I.R. Iran.
MANSOOR
RASTEGARPANAH
20031947532846004808
20031947532846004808
No
From the Department of Pharmacotherapy (Clinical Pharmacy). Faculty of Pharmacy. Tehran University of Medical Sciences