Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1376
11
1
gregorian
1998
2
1
11
4
online
1
fulltext
en
BRONCHODILATORY AND AN TICHOLINERGIC EFFECTS OF Carum copticum ON ISOLATED GUINEA PIG TRACHEAL CHAINS
Physiology
Physiology
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
Carum copticum is a grassy and annual plant which is believed to have several
therapeutic effects, including anti-asthmatic properties.
We have therefore studied the bronchodilatory and anticholinergic effects of
4 rnL aqueous extract (AE), 0.0 5 mL ethanol extract (EE), and 0.0 0 5 mL essential
oil (EO) of Carum copticum and 1 rnL of a 5 mM solution of its main ingredient,
thymol (T), in comparison with 4 mL of saline (S) on isolated tracheal chains of
guinea-pigs (w=500-800 g) in a 50 mL organ bath. The bronchodilatory effects of
different solutions were examined by their relaxant effect on isometrically (1 g)
precontracted tracheal chains by 10 µM methacholine (M). The anticholinergic
effects of different solutions were tested by comparing the cumulative log
concentration -response curves of tracheal chains to cumulative concentrations of
M in the presence of AE, EE, EO, and T with that of S.
The bronchodilatory effects of AE, EE, and EO were significantly higher than
S in all cases (p<0.00 1), but T did not show any significant bronchodilatory effect.
There were also significant right-ward shifts in cumulative log concentrationresponse
curves obtained in the presence of AE, EE, and EO in comparison with
the curve obtained in the presence of S. Thymol also caused a smaller right-ward
shift in the M cumulative log concentration-response curve . However, the slopes
of methacholine response curves obtained in the presence of AE, EE, EO
(p<0 .00 l ), and T (p<0.05) were significantly lower than that of S, indicating the
functional antagonistic effects of these solutions.
These data showed the presence of bronchodilatory effects of AE, EE, and EO
of Carum copticum which was not due to the presence of T or the existence of a
competitive antagonist at the muscarinic receptors in this plant.
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334
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-337&slc_lang=en&sid=1
MH
BOSKABADY
20031947532846005015
20031947532846005015
Yes
From the Dept. of Physiology, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, I. R.lran.
H
RAKHSHANDAH
20031947532846005016
20031947532846005016
No
V
MOETAMED SHARIATI
20031947532846005017
20031947532846005017
No