Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1376
5
1
gregorian
1997
8
1
11
2
online
1
fulltext
en
COMPARISON OF ANTIULCER EFFECTS OF TRICYCLIC ANTIDEPRESSANTS WITH CIMETIDINE AND OMEPRAZOLE IN RATS
Pharmacology
Pharmacology
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
The antiulcer effects of different tricyclic antidepressants (trimipramine,
doxepin, imipramine, and amitriptyline) in comparison with those of cimetidine,
pirenzepine and omeprazole were investigated in male rats with acute gastric
ulcer. Acute gastric ulcer was induced by oral administration of O. 6N HCl solution,
1 mL/rat.
Pretreatment of animals with doxepin, trimipramine, amitriptyline, imipramine
(in doses of 10, 25, 40, 50, and 75 mg/kg, SC), cimetidine (in doses of 50,75, 100,
150 and 200 mg/kg, SC), omeprazole and pirenzepine (in doses of 10, 20, 30,40
and 50 mg/kg, SC) inhibited the formation of erosions dose-dependently.
The ED 50 of these agents revealed that the most active agents were omeprazole,
doxepin and pirenzepine, followed by trimipramine and cimetidine. Imipramine
and amitriptyline had slight antiulcer activity.
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125
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-375&slc_lang=en&sid=1
HAMID REZA
JAMSIDDI
20031947532846005176
20031947532846005176
Yes
From the Department of Pharmacology, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.
TAGHI
GHAFGHAZI
20031947532846005177
20031947532846005177
No