Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1376
2
1
gregorian
1997
5
1
11
1
online
1
fulltext
en
ANTINEUTROPHIL CY TOPLASMIC AUTOANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS
Immunology
Immunology
Original Research
Original Research
Antineutrophil cytoplasmic autoantibodies (ANCA) were first described in
patients with necrotizing glomerulonephritis. The original observation passed
unnoticed until an association was made between ANCA and active Wegener's
granulomatosis. Since then, tremendous progress has been made in elucidating the
association between ANCA subtypes and clinicopathologic syndromes, and the
potential pathologic role of ANCA in vascular inflammation. The gold standard
method for ANCA detection is indirect immunofluorescence (IIF) microscopy of
ethanol-fixed cells. By this technique two general patterns of ANCA, acytoplasmic
pattern (c-ANCA) and a perinuclear pattern (P-ANCA) can be identifed. Recently
some reports have been published concerning the prevalence, subtypes, role and
specificity of ANCA.ln this study we searched for ANCA prevalence, subtypes,
and its relationship with disease activity in SLE patients by IIF technique. Our
results showed that all normal subjects were ANCA negative, while at least 50%
of patients were ANCA positive (majority c-ANCA type). Statistical analysis
revealed that there is no correlation between the presence of ANCA and disease
activity (p<0.01).
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http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-394&slc_lang=en&sid=1
M
VODJGANI
20031947532846005226
20031947532846005226
Yes
From the Dept. of lmmunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
F
NASSIRI ZADEH
20031947532846005227
20031947532846005227
No
J
HADJATI
20031947532846005228
20031947532846005228
No
M
AKBARlAN
20031947532846005229
20031947532846005229
No