Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1388
11
1
gregorian
2010
2
1
23
4
online
1
fulltext
en
Transverse myelitis and heroin abuse: a case report
Midwifery and Reproductive Health
Applicable
Applicable
<p> <strong> Abstract </strong></p><p> The usage of heroin is associated with a variety of neurologic disorders, including </p><p> acute transverse myelitis. In this study we present a 19 year old man who was suffered </p><p> from insufflated heroin after several months of abstinence, and admitted to hospital </p><p> emergency department, unconscious. He responded to fluid therapy and Naloxone, </p><p> but could not move his legs on examination. He had flaccid paralysis of both </p><p> legs, acute urinary retention and diminished rectal tone. Deep tendon reflexes were </p><p> absent with downward plantar reflexes. Analysis of CSF was normal, and the MRI of </p><p> the spine revealed confluent hyperintensity on T2-weighted images from the C5 to </p><p> T2 vertebral levels involving the majority of the cord substance. The cord was mildly </p><p> expanded without any enhancement after Gadolinium injection. Suggested mechanisms </p><p> of heroin-associated myelopathy include hypotension, a direct toxic effect of </p><p> heroin, vasculitis, and hypersensitivity reaction. Hypersensitivity was the predominant </p><p> theory since the initial reports, implied that most patients with developed </p><p> myelopathy had relapsed into heroin use after a period of abstinence. Treatment with </p><p> either IV corticosteroids or immunopheresis could blunt the immune response, preventing disability. Efficacy of these methods require more studies in future. </p><p> </p>
transverse myelitis, drug abuse, heroin
238
240
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-91&slc_lang=en&sid=1
Bahram
Haghi-Ashtiani
bhaghi2000@yahoo.com
20031947532846001898
20031947532846001898
Yes
Baradaran Rezaei Hospital, Damghan, Semnan, Iran.
Farzad
Sina
20031947532846001899
20031947532846001899
No
Fowzieh
Ben Isa
20031947532846001900
20031947532846001900
No
Iran University of Medical Sciences, Tehran, Iran.
Mohammad
Rohani
20031947532846001901
20031947532846001901
No