Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1389
2
1
gregorian
2010
5
1
24
1
online
1
fulltext
en
In vitro antifungal activity of Allium hirtifolium in comparison with miconazole
Parasitology and Mycology
Parasitology and Mycology
Original Research
Original Research
<p> <strong> Abstract </strong><strong></strong></p><p> <strong> Objective: </strong>Shallots are important part of the diet for many people and there is </p><p> long-held belief in their health enhancing properties. The aim of this study was to determine antifungal activity of shallot against reference fungal strains. </p><p> <strong> Methods: </strong>Alcoholic and aqueous extracts of shallot (Allium hirtifolium) were </p><p> tested for in vitro antifungal activities against Aspergillus fumigatus, Aspergillus </p><p> flavus, Aspergillus niger, Penicillium gryseogenum, Alternaria, Microsporum canis </p><p> and Trichophyton mentagrophytes. The minimal inhibitory concentration (MIC) </p><p> was determined using broth macrodilution method. The effects of shallot extracts </p><p> were also compared with those of miconazole. </p><p> <strong> Results: </strong>Allium hirtifolium showed antifungal activity against all the </p><p> fungi species tested with MIC values ranging from 0.058 to 0.8 mg/ml for alcoholic </p><p> extract and 0.26 to 3.84 mg/ml for aqueous extract. The minimum fungicidal concentration (MFC) of alcoholic and aqueous extracts ranged from 0.1 to 12.8 mg/ml and 0.6 to 68.26mg/ml, respectively. </p><p> <strong> Conclusions: </strong>The results indicate that crude juice of shallot has antifungal activity </p><p> and might be promising, at least, in treatment of fungal-associated diseases from </p><p> mentioned fungi. </p><p> </p>
Allium hirtifolium, Miconazole, Aspergillus spp, Alternaria, Penicillium chrysogenum, Microsporum canis, Trichophyton mentagrophytes
17
22
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-94&slc_lang=en&sid=1
Roohollah
Fateh
20031947532846001916
20031947532846001916
No
Department of parasitology and Mycology, Iran University of Medical Sciences,Tehran, Iran
Mohammad Javad
Nasiri Kashani
20031947532846001917
20031947532846001917
No
Department of Parasitology and Mycology, Iran University of Medical Sciences,Tehran, Iran.
Manijheh
Motevallian
20031947532846001918
20031947532846001918
No
Razi Institue for Drug Research,Tehran, Iran.
Mehraban
Falahati
mehrabanfalahati@yahoo.com
20031947532846001919
20031947532846001919
Yes
Department of Parasitology and Mycology, Iran University of MedicalSciences,Tehran, Iran.
Amir
Yazdanparast
20031947532846001920
20031947532846001920
No
Department of Parasitology and Mycology, Iran University of Medical Sciences,Tehran, Iran