Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1366
8
1
gregorian
1987
11
1
1
1
online
1
fulltext
en
RESISTANCE OF PLASMODIUM FALCIPARUM TO CHLOROQUINE IN SOUTH EASTERN IRAN
Health
Health
Original Research
Original Research
In vivo and in vitro assessments of the response of P. falciparum to
chloroquine using WHO standard kits and techniques were carried out in
I ran Shahr, Sistan and Baluchestan province of Iran in 1985.
In the in vivo assessment, 24 malaria patients treated with chloroquine
(25mg/kg over three days) were followed up for one to four weeks. The mean
parasite clearance time was 4.3 days and in two cases, recrudescence
occurred on the 20th and 22nd day.
In the micro in vitro test, from among 87 samples, the growth of the
parasites was satisfactory in 11 cases (12.6%) and the development of the
parasites continued in the presence of higher doses of chloroquine (1.14 to
6.4 micromol/l blood).
In the macro in vitro test, from 28 successful tests, the growth of the
parasites continued in the presence of higher doses of chloroquine (1.25 to 3
micromol/l blood) in eight cases (28.5%).
The present study showed resistance of P. falciparum to chloroquine in
Iran Shahr area, southeastern Iran, and confirmed the results of the
preliminary studies carried out in this area in 1983.
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http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-541&slc_lang=en&sid=1
GH
EDRISSIAN
20031947532846005732
20031947532846005732
Yes
From the School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences.Tehran. Islamic Republic of Iran
A
AFSHAR
20031947532846005733
20031947532846005733
No
A
KANANI
20031947532846005734
20031947532846005734
No
MT
SATVATAND
20031947532846005735
20031947532846005735
No
M
GHORBANI
20031947532846005736
20031947532846005736
No