Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1387
11
1
gregorian
2009
2
1
22
4
online
1
fulltext
en
Evaluation of preoperative elevation of serum c-reactive protein as an indicator for prognosis of colorectal cancer
Surgery
Surgery
Original Research
Original Research
<p> <strong> Abstract </strong><strong></strong></p><p> <strong> Background </strong>: Cancer has not been elucidated in colerectal site. C-reactive protein </p><p> (CRP) is a product synthesized in hepatocytes and has been reported to be up-regulated </p><p> by such proinflammatory cytokines as interleukin-1 (IL-1), interleukin-6 (IL-6), </p><p> and tumor necrosis factor (TNF). The significance of a preoperative serum elevation </p><p> was evaluated using CRP as a predictive indicator for the malignant potential and </p><p> prognosis. </p><p> <strong> Methods: </strong>Forty consecutive patient with colorectal cancer whose local lesions </p><p> were resected in our department, plus forty healthy volunteers, were selected. Any </p><p> patient with inflammatory diseases such as infection or collagen disease was excluded </p><p> from the current study. The preoperative serum CRP level and the control group </p><p> were measured. The relationships between the serum elevation of CRP and both the </p><p> clinicopathologic factors and prognosis of the patients was investigated. </p><p> <strong> Results: </strong>The rate of patients with elevated serum CRP level was significantly </p><p> higher in the colorectal cancer patients in comparison to the control group (55% versus </p><p> 2.5%). Furthermores the incidence of liver metastasis, peritoneal carcinomatosis, </p><p> histopathologic lymph nodes metastasis, and tumor invasion in colorectal cancer patients </p><p> with a preoperatively elevated serum CRP level were significantly more frequent </p><p> than in those with a negative serum CRP level. The survival rates of the colorectal </p><p> cancer patients without a preoperative elevation of the serum CRP proved to </p><p> be significantly more favorable than that of the colorectal cancer patients with such </p><p> an elevation (94.4% versus 59.1% P<0.001). </p><p> <strong> Conclusion: </strong>Apreoperative serum elevation of CRP was thus found to be an indicator </p><p> of the malignant potential of the tumor as well as prognostic factor for patients </p><p> with colorectal cancer. </p><p> </p>
C-reactive protein,colorectal cancer.
164
169
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-11&slc_lang=en&sid=1
Seyed Reza
Mousavi
20031947532846001665
20031947532846001665
No
Shahid Beheshti University of Medical Sciences, Shohada-e-Tajrish Hospital,
Arash
Najaf beygi,
a.najafbeygi@yahoo.com
20031947532846001666
20031947532846001666
Yes
Shahid Beheshti University of Medical Sciences, Shohada-e-Tajrish Hospital,
Mohsen
Talebianfar
20031947532846001667
20031947532846001667
No
Shahid Beheshti University of Medical Sciences, Shohada-e-Tajrish Hospital,
Mohamad
Zeinalzadeh
20031947532846001668
20031947532846001668
No
Shahid Beheshti University of Medical Sciences,
Ataollah
Heidari
20031947532846001669
20031947532846001669
No
Shahid Beheshti University of Medical Sciences,