Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1374
2
1
gregorian
1995
5
1
9
1
online
1
fulltext
en
THE DISTURBANCES IN IRON TRANSPORT AND STORES AND TOTAL FREE RADICAL TRAPPING ABILITY OF BLOOD PLASMA IN BABIES WITH MITOCHONDRIAL ENCEPHALO MYOPATHIES
Pharmacology
Pharmacology
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
Babies with mitochondrial encephalomyopathies had higher ferritin levels
than controls. Although plasma iron levels were simi lar in both groups, babies with
mitochondrial encephalomyopathies had lower transferrin levels. Thiobarbituric
acid reactive substances in plasma of babies with mitochondrial
encephalomyopathies were higher thun in controls suggesting increased lipid
oxidation. We studied the total radical trapping capacity of the antioxidants in
plasma (TRAP) and compared the TRAP level in children with mitochondrial
encephalomyopathies with that in healthy controls. I n addition, the concentrations
of various known antioxidants were measured and the theoretical contribution of
these antioxidants to the TRAP calculated. The measured and calculated TRAP
were higher in the control group than the group of children with mitochondrial
encephalomyopathies. Uric acid, vitamins E and C and sulphides concentrations
were lower in children with mitochondrial encephalomyopathies compared with
controls. The main conclusion from this work is that forchildren with mitochondrial
encephalomyopathies, plasma contents of vitamin E, vitamin C, and cysteine-rich
proteins which are all essential nutrients are too low for optimal activity of
antioxidant systems.
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http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-556&slc_lang=en&sid=1
A
JENDRYCZKO
20031947532846005966
20031947532846005966
Yes
From the Department of Drag Chemistry, Silesian School of Medicine, 41-200 Sosnowiec
E
MARSZAL
20031947532846005967
20031947532846005967
No
M
KRAUZE
20031947532846005968
20031947532846005968
No