Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1373
11
1
gregorian
1995
2
1
8
4
online
1
fulltext
en
TRIAL OF A NON-LIVING CRUDE VACCINE AGAINST ZOONOTIC CUTANEOUS LEISHMANIASIS
Health
Health
Original Research
Original Research
A field trial was canied outon60 volunteers selected in Yazd province, central
Iran, with a vaccine containing killed promastigotes of L. major prepared by the Razi
Institute, Hessarak. During these phase I studies which lasted for more than two
years, we examined acceptable doses of the vaccine alone or mixed with BCG. The
results so far indicate that 50 to 1000 µg of the vaccine alone can be well tolerated
without major side-effects. The mixture of BCG with 400 µg of the vaccine produced
pain and itching in five out of six volunteers, a self-limiting lymphadenopathy in one
out of six, and fever in three out of six. Further trials are planned with reduced doses
of BCG. The leishmania skin test became positive in a high proportion of the treated
individuals after vaccination. Circulating antibodies were detected from two weeks
to one month after vaccination.
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215
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-560&slc_lang=en&sid=1
M
MOHEBALI
20031947532846005976
20031947532846005976
Yes
From the School of Public Health and Institute of Public Health research, Tehran university of Medical Science
EH
JAVADlAN
20031947532846005977
20031947532846005977
No
From the School of Public Health and Institute of Public Health research, Tehran university of Medical Science
R
FESHARAKl
20031947532846005978
20031947532846005978
No
Department of Protozoology and Entomology, Razi State Serum Vaccine Institute, Tehran,
M
MOHAMMADZADEH
20031947532846005979
20031947532846005979
No
Amir al –Momenin Hospital, Shahid Sadooghi University of Medical Sciences, Yazd. Islamic Republic of Iran.
A
NADlM
20031947532846005980
20031947532846005980
No
From the School of Public Health and Institute of Public Health research, Tehran university of Medical Science
GH
TAHYILDAR-BIDRUNI
20031947532846005981
20031947532846005981
No
From the School of Public Health and Institute of Public Health research, Tehran university of Medical Science
A
MESDAGHINIA
20031947532846005982
20031947532846005982
No
From the School of Public Health and Institute of Public Health research, Tehran university of Medical Science