Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1373
8
1
gregorian
1994
11
1
8
3
online
1
fulltext
en
AUTOANTIBODIES AGAINST THYR OID CONSTITUENTS AND CIC IN GRAVES' DISEASE ASSOCIATED WITH EXOPH THALMUS
Immunology
Immunology
Original Research
Original Research
32 patients (19 female. 13 male)• suffering from Graves' disease with
exophthalmus and five without exophthalmus were studied for various autoantibodies
including anti-thyroglobulin (ATAB). anti-microsomal antibody (AMAB).
anti-parietal antibodies (APAB) and also circulating immune complex (CrC). 43
normal subjects were tested concurrently.
Immunofluorescent technique was employed for autoantibody detection.
Frozen sections of human thyroid tissue and rat stomach were utilized as antigen
sources for thyroid and parietal CIC estimated by PEG (polyethylene glycol)
precipitation method and the specific classes of immunoglobulins were detected
by SRlD (single radial immunodiffusion).
The results were analyzed statistically. From the point of view of presence of
antibodies. there were significant differences between patients and control groups
(P= 0.(05). Comparing Graves' with or without exophthalmus. no significant
difference was seen between autoantibody levels. but higher titers of CIC were
elucidated in the latter group.
We will discuss that autoantibodies have an important role in thyroid
autoimmune diseases and also that CIC may have a critical role in the pathogenesis
of exophthalmus associated with Graves' disease
149
153
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-575&slc_lang=en&sid=1
S
RAFIEI
20031947532846006018
20031947532846006018
Yes
From the Dept. of Immunology School of Medicine, Tehran University of Medical Sciences, Tehran
M
NAKHJEVANI
20031947532846006019
20031947532846006019
No
From the Dept. of Endocrinology, School of Medicine, Tehran University of Medical Sciences, Tehran
M
GHARAGOUZLOU
20031947532846006020
20031947532846006020
No
Bu Ali Sina University of MedicalSciences, Hamedan University, Hamedan, I.R.Iran.