Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1373
8
1
gregorian
1994
11
1
8
3
online
1
fulltext
en
LEVELS OF SOLUBLE IL-2 RECEP TORS IN SERA OF IRANIAN PATIENTS WITH BEHCET'S DISEASE
Immunology
Immunology
Original Research
Original Research
It has been shown that activated T-cells produce and release both IL-2 and IL-
2 receptors (lL-2R). The rate of IL-2 release is proportional to its cell surface
expression and state of cell activation. To clarify the molecular basis of this
immunological aberration, we analysed the amount of soluble IL-2R(SIL2-R) by
an ELISA technique in 68 patients with Behcet's disease (BD), 28 patient controls
(PC) and 31 normal controls (NC).
The data suggest that the amount of SIL-2R in BD is significantly higher
(P<O.005) than that of NC. The same differences were seen between PC and
NC(P<O.005). However the level of S IL-2R in BD and PC were similar.
This study suggests that inhibition of an immunoregulatory cytokine by its
soluble receptors might occur ill vivo, as the reduction ofS IL-2R levels approaching
control values preceded clinical remission.
163
166
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-578&slc_lang=en&sid=1
M
RAIANI
20031947532846006026
20031947532846006026
Yes
From the Department of Immunology Shariati Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
A
MASSOUD
20031947532846006027
20031947532846006027
No
From the Department of Immunology Shariati Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
F
DAVATCHI
20031947532846006028
20031947532846006028
No
From the Department of Rheumatology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.