Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1371
11
1
gregorian
1993
2
1
6
4
online
1
fulltext
en
BUPROPION-INDUCE D CLIMBING THROU GH D -1 AND D-2 DOPAMINE RECEPTOR ACTIVATION
Pharmacology
Pharmacology
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
Intraperitoneal (IP) injection of bupropion (3,6,
amine (4,16 mg kg•') induced dose-dependent climbing in mice. The climbing
response induced by both drugs were decreased in animals pretreated either with
the 0-1 antagonist SCH 233<)0 or the 0-2 antagonist sulpiride. The α-adrenoceptor
blocker phenoxybenzamine decreased the climbing induced by both bupropion
and amphetamine, but the β-adrenergic blocker propranolol and the antimuscarinic
agent atropine had no effect. Reserpine pretreatment abolished the climbing
induced by bupropion but not that of amphetamine. However, alpha-methyl-ptyrosine
combined with reserpine treatment reduced the amphetamine-induced
climbing. It is concluded that both bupropion and amphetamine-induced climbing
through release of dopamine and subsequent activation of 0-1/0-2 receptors
however, the mechanisms by which dopamine is released by these drugs may
differ.
D-1and D-2 receptors, amphetamine, bupropion. reserpine, climbing. Mice
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289
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-676&slc_lang=en&sid=1
MOHAMMAD-REZA
ZARRINDAST
20031947532846006264
20031947532846006264
Yes
From the Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
YADOLLAH
KHAlENABI
20031947532846006265
20031947532846006265
No
MOHAMMAD HOSSEIN
POURGHOLAMI
20031947532846006266
20031947532846006266
No