Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1379
8
1
gregorian
2000
11
1
14
3
online
1
fulltext
en
EFFECTS OF CCK RECEPTOR AGONISTS AND ANTAGONISTS ON MORPHINE-INDUCED ANTINOCICEPTION IN MICE
Pharmacology
Pharmacology
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
In the present study the effects of both CCK receptor agonists and antagonists
on antinociception induced by morphine in the tail-flick test have been evaluated.
M orphine induced dose-dependent antinociception in mice. The response of
morphine was potentiated by sulfated cholecystokinin-8 (CCK-8S) but not by
unsulfated cholecystokinin-8 (CCK-8U). The CCK receptor antagonists MK-329
and L-365, 260 decreased the potentiation of morphine antinociception induced
by CCK-8S.•The antagonists even decreased the response induced by morphine
in the pre5ence ofCCK-8U. High doses ofMK-329 and L-365, 260 also potentiated
morphine's antinociception. Single administration of the CCK receptor agonists
CCK-8 and CCK-8U or CCK receptor antagonists did not elicit any response
in the tail-flick test. It is concluded that CCK receptor mechanisms are
involved in the modulation of pain response and/or morphine antinociception.
CCK agents, morphine, antinociception, mice
261
266
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-847&slc_lang=en&sid=1
MR
ZARRINDAST
20031947532846006850
20031947532846006850
Yes
From the Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran.
M
REZAYAT
20031947532846006851
20031947532846006851
No
From the Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran.
MR
ZOLFAGHARPOOR
20031947532846006852
20031947532846006852
No
From the Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran.