Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1389
8
1
gregorian
2010
11
1
24
3
online
1
fulltext
en
Effect of oral supplementation of zinc on treatment of otitis media with effusion
Otorhinolaryngology
Otorhinolaryngology
Original Research
Original Research
<p> <strong> Abstract </strong><strong></strong></p><p> <strong> Objective: </strong>To determine the effect of oral zinc sulfate supplementation given with </p><p> coamoxiclav when compared with coamoxiclav alone for treatment of otitis media </p><p> with effusion (OME). The efficacy of the drug was assessed 3 and 6 weeks after administration . </p><p> <strong> Methods: </strong>In a double-blind, randomized trial 4 to 14 years old children with OME </p><p> who referred to ear, nose and throat clinic, were randomly assigned into two groups : </p><p> 1) Zinc group: Zinc sulfate + Coamoxiclav + Pseudoephedrine + Nacl nasal drop </p><p> 2) Placebo group: Placebo + Coamoxiclav + Pseudoephedrine + Nacl nasal drop . </p><p> Atotal of 52 children were studied consisting zinc group 29 and placebo group 23 </p><p> children. Children were examined by otoscopy and tympanometry at entry and after </p><p> 3 weeks of treatment. For children who had not been cured completely after 3 weeks , </p><p> treatment continued for more 3 weeks (total of 6 weeks ( . </p><p> <strong> Results: </strong>At the end of the first course of treatment (3 weeks) 62.1% of children in </p><p> the zinc group had clinical improvement compared with 43.5% of children in placebo </p><p> group. Tympanometrically, 70.9% of children in zinc group had improvement </p><p> compared with 65.5% for placebo group with no statistically significant difference . </p><p> There was no significant difference between the two groups at the end of second </p><p> course of treatment (6 weeks). But the response rate of zinc group was better than the </p><p> placebo group (43.8% versus 12.5% clinically and 56.3% versus 40% tympanometricall). Zinc administration and cycles of treatment had no significant relationship . </p><p> <strong> Conclusion: </strong>Although in this study oral zinc sulfate supplementation had not significant effect on treatment of OME, the response rate was better in zinc group compared to placebo group specially in longer administration . According to the findings, it seems more studies about oral zinc supplementation </p><p> in the treatment of OME is needed . </p>
supplementation of zinc, otitis media with effusion, tympanometry
126
132
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-115&slc_lang=en&sid=1
Poopak
Izadi
popakizadi@yahoo.com
20031947532846001417
20031947532846001417
Yes
Shahed University, Tehran, Iran
Mohammad-ebrahim
Yarmohammadi
yarmohammadime@yahoo.com
20031947532846001418
20031947532846001418
No
Shahed University, Tehran, Iran
Nahid
Kholdi
kholdi_nahid@yahoo.com
20031947532846001419
20031947532846001419
No
Shahed University, Tehran, Iran
Babak
Izadi
Bizadi@hotmail.com
20031947532846001420
20031947532846001420
No
Kermanshah University, Kermanshah, Iran
Sasan
Anari
A_sassan60@yahoo.com
20031947532846001421
20031947532846001421
No
Morteza
Sedehi
Sedehi56@yahoo.com.
20031947532846001422
20031947532846001422
No
Shahed University, Tehran, Iran