Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1392
8
1
gregorian
2013
11
1
27
4
online
1
fulltext
en
Role of matrix metalloproteinases (MMPs) and MMP inhibitors on intracranial aneurysms: a review article
Neurosurgery
Neurosurgery
Review Article
Review Article
<font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 10pt text-align: justify text-justify: inter-ideograph"><font size="3"><font face="Calibri">Cerebrovascular
disease is one of the leading causes of death in the world, and about
one-fourth of cerebrovascular deaths are due to ruptured cerebral aneurysms
(CA). Hence it is important to find a way to reduce aneurysm formation and its
subsequent morbidity and mortality. Proteolytic activity capable of lysing
gelatin has been shown to be increased in aneurysm tissue and expression of
plasmin, membrane-type matrix metalloproteinase- 1(MT1-MMP), and matrix
metalloproteinase-2 (MMP-2) in aneurysmal wall is more than what we observe in
normal cerebral arteries. MMP inhibitors such as doxycycline and statins may
prohibit aneurysm formation and growth. MMPs are important in tissue remodeling
associated with various physiological and pathological processes such as
morphogenesis, angiogenesis, apoptosis and tissue repair. In this article we
review the role of MMPs and MMP inhibitors in formation of aneurysm.<o:p /></font></font></p><font face="Times New Roman" size="3"> </font>
Cerebral aneurysm, MMPs, MMP inhibitors, Doxycycline, Statins.
249
254
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-604&slc_lang=en&sid=1
Azam
Maradni
azam.mardani@yahoo.com
20031947532846009034
20031947532846009034
No
Brain and spinal injury repair research center (BASIR), Tehran University of Medical Sciences, Tehran, Iran.
Alireza
Khoshnevisan
akhoshnevisan@tums.ac.ir
20031947532846009035
20031947532846009035
Yes
Department of Neurosurgery, Brain and spinal injury repair research center, Tehran University of medical sciences, Tehran, Iran.
Seyed Hamzeh
Mousavi
shm135978@yahoo.com
20031947532846009036
20031947532846009036
No
Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran.
Seyed Hasan
Emamirazavi
emami_r@health.gov.ir
20031947532846009037
20031947532846009037
No
Department of Surgery, Brainand spinal injury repair research center (BASIR), Tehran University of Medical Sciences,Tehran, Iran.
Abbas
Noruzijavidan
noroozi@tums.ac.ir
20031947532846009038
20031947532846009038
No
Brain and spinal injury repair research center, Tehran University of Medical Sciences, Tehran, Iran.