Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1392
10
1
gregorian
2014
1
1
28
1
online
1
fulltext
en
Deep brain stimulation of globuspallidusinternus for DYT1 positive primary generalized dystonia
Neurology
Neurology
Original Research
Original Research
<p> <strong> Background </strong>: Deep brain stimulation (DBS) of the globuspallidusinternus (GPi) is recommended as a promising technique for the management of the primary generalized dystonia (PGD) with DYT1 gene mutation. We present the first report of DBS results in Iranian patients with DYT1 positive PGD.<i /> </p><p> <strong> Methods </strong>: Nine patients who suffered from severely disabling DYT1 positive PGD consecutively were recruited for the study between 2008 and 2010. The patients underwent bilateral deep brain stimulation of the GPi in a single procedure. The mean follow up duration was 8.8 ± 2.2 months. The efficacy of the intervention was evaluated by comparing pre- and post operative scores of patients with Burke-Fahn-Marsden's dystonia Scale (BFMDS). Statistical analysis was performed using SPSS 11.0 software. <i /></p><p> <strong> Results: </strong>Of 9 patients six were female with the mean age of 15.2 ± 5.5 years old (range: 8- 25 years old). The mean for Burke-Fahn-Marsden's Dystonia Rating Scale (BFMDRS) score was 47.22 ± 14.1 before surgery and 12.3 ± 8.2 after follow up, which significantly improved (P=0.0001).The mean stimulation parameters at the last visit were at a frequency of 152.2 ± 32.4 Hz (range 130- 230 Hz), a voltage of 2.6 ± 0.7 V (range 1.1- 4), and a pulse width of 60 μsec. No complication was observed during follow up. <i /></p><p> <strong> Conclusion: </strong>Bilateral DBS of the GPi has an encouraging result for the management of DYT1 positive PGD and is recommended as a safe technique for the treatment of these patients. Shorter pulse width in stimulation parameters is suggested for DYT1 dystonia patients. <i /></p>
Deep brain stimulation, Globus pallidusinternus, DYT1 dystonia.
119
123
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-646&slc_lang=en&sid=1
Shahnaz
Miri
shz_miri@yahoo.com
200319475328460012965
200319475328460012965
No
State University of New York, Downstate Medical Center, Department of Neurology, Brooklyn, NY 11203, USA.
Esmaeil
Ghoreyshi
esighoreyshi@yahoo.com
200319475328460012966
200319475328460012966
No
Iran University of Medical Sciences, Department of Neurology, Rasool-Akram Hospital, Tehran, Iran.
Gholam Ali
Shahidi
gshahidi@hotmail.com
200319475328460012967
200319475328460012967
No
Iran University of Medical Sciences, Department of Neurology, Rasool-Akram Hospital, Tehran, Iran.
Mansour
Parvaresh
m_parvaresh@yahoo.com
200319475328460012968
200319475328460012968
No
Iran University of Medical Sciences, Department of Neurosurgery, Rasool-Akram Hospital, Tehran, Iran.
Mohammad
Rohani
mohammadroohani@gmail.com
200319475328460012969
200319475328460012969
Yes
Iran University of Medical Sciences, Department of Neurology, Rasool-Akram Hospital, Tehran, Iran.
Mehdi
Saffari
mehdisaffari_hn@yahoo.com
200319475328460012970
200319475328460012970
No
Iran University of Medical Sciences, Department of Neurology, Rasool-Akram Hospital, Tehran, Iran.