Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1393
10
1
gregorian
2015
1
1
29
1
online
1
fulltext
en
Protective role of Proanthocyanidin in experimental ovarian torsion
Pediatric
Pediatric
Original Research
Original Research
<p> <strong> Background: </strong>Proanthocyanidin is a potent bioactive antioxidant naturally occurring in grape seed and acts as reactive oxygen species (ROS) scavenger. The aim of this study was to investigate the effects of proanthocyanidinin in experimental ovarian torsion injury. </p><p> <strong> Methods </strong>: Twenty four rats were randomly divided into three groups (n=8). Group 1: the laparotomy group, group 2: ovarian torsion group, and group 3: intervention group administered proanthocyanidinin of 50 mg/kg before bilateral ovarian ischemia and reperfusion. Histologic examination and scoring was done at the end of the experiment. Statistical analyses were performed using the SPSS v. 19. </p><p> <strong> Results </strong>: Ovarian histopathologic findings of all three groups were significantly different in terms of hemorrhage (p<0.001), edema (p=0.001) and vascular dilatation (p< 0.001). Pathologic changes induced by I/R were reduced in ovaries of rats administered proanthocyanidin, in particular, hemorrhage, edema and vascular dilatation. </p><p> <strong> Conclusion </strong>: Proanthocyanidin, known as free radical scavenger and antioxidant, is protective against tissue damage induced by ischemia and/or ischemia/reperfusion in rat ovaries. </p>
Proanthocyanidinin, Fertility, Ischemia Reperfusion, Ovarian torsion.
210
215
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-802&slc_lang=en&sid=1
Şule
Yıldırım
sule.yildirim@comu.edu.tr
200319475328460015197
200319475328460015197
Yes
Department of Pediatrics, Faculty of Medicine, ÇanakkaleOnsekiz Mart University, Çanakkale, Turkey.
Naci
Topaloğlu
nacitopaloglu@gmail.com
200319475328460015198
200319475328460015198
No
Department of Pediatrics, Faculty of Medicine, ÇanakkaleOnsekiz Mart University, Çanakkale, Turkey.
Mustafa
Tekin
mustafa5060@gmail.com
200319475328460015199
200319475328460015199
No
Department of Pediatrics, Faculty of Medicine, ÇanakkaleOnsekiz Mart University, Çanakkale, Turkey.
Adem
Küçük
ademkucuk81@hotmail.com
200319475328460015200
200319475328460015200
No
Department of Pediatric Surgery, Düzce Atatürk State Hospital, Düzce, Turkey.
Havva
Erdem
drhavvaerdem@hotmail.com
200319475328460015201
200319475328460015201
No
Department of Pathology, Düzce University Medical Faculty, Düzce, Turkey.
Mesut
Erbaş
benimmesut@hotmail.com
200319475328460015202
200319475328460015202
No
Department of Anesthesiology, Faculty of Medicine, ÇanakkaleOnsekiz Mart University, Çanakkale, Turkey.
Ahmet
Yıldırım
. ahmetyildirim@comu.edu.tr
200319475328460015203
200319475328460015203
No
Department of Emergency Medicine, Faculty of Medicine, ÇanakkaleOnsekiz Mart University, Çanakkale, Turkey.