Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1393
10
1
gregorian
2015
1
1
29
1
online
1
fulltext
en
Anti-hemorrhagic activity of Punicagranatum L. flower (Persian Golnar) against heavy menstrual bleeding of endometrial origin: a double-blind, randomized controlled trial
Gynecology & Obstetrics
Gynecology & Obstetrics
Original Research
Original Research
<p> <strong> Background: </strong>Heavy menstrual bleeding of endometrial origin (HMB) is a major healthcare problem in premenopausal women and affects several aspects of women’s health and quality of life (QoL). The aim of this study was to compare the efficacy of Persian Golnar (PG) and tranexamic acid (TA) on heavy menstrual bleeding of endometrial origin (HMB) and patients’ QoL. </p><p> <strong> Methods </strong>: A double-blind randomized controlled trial with parallel design and block randomization technique was conducted. A total of 94 women with HMB were randomly assigned to take either PG or TA for 5 days from day 1 of menses for three consecutive menstrual cycles. Blood loss was measured by the pictorial blood loss assessment chart (PBAC). Hematological assessments were made before the intervention and after treatment. QoL as a secondary outcome was evaluated using SF-36 and the menorrhagia questionnaire (MQ). Statistical analysis was performed using t-test, paired t-test, χ2 test, Mann–Whitney test, and Wilcoxon signed-rank test. </p><p> <strong> Results </strong>: In each group, 38 women (80.8%) completed the 3-month follow-up. Both PG and TA reduced blood loss. PBAC mean (SD) score was reduced from 304.92 (176.17) and 304.44 (192.72) to 164.60 (100.24) and 143.13 (96.07) after the third treatment cycle, respectively (p<0.001). Furthermore, mean hemoglobin, Hb (SD) concentrations in the PG and TA groups increased significantly from 12.06(0.86) and 11.53(0.86)mg/dl to 13.02 (0.82) and 12.72 (0.88)mg/dl (p< 0.001). QoL was significantly improved in both groups (p< 0.001). However, there were no significant differences between the groups after the intervention. </p><p> <strong> Conclusion </strong>: The results of the present study demonstrate the efficacy of PG in treating HMB in terms of clinical and QoL indicators. </p>
Menstrual disturbance, Bleeding, Iran, Punicagranatum, Tranexamic acid.
325
332
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-836&slc_lang=en&sid=1
Azita
Goshtasebi
agoshtasebi@ihsr.ac.ir & azita_goshtasbi@yahoo.com
200319475328460016465
200319475328460016465
Yes
Family Health Research Group, Health metrics Research center, Iranian Institute for Health Sciences Research, ACECR, Tehran, Iran.
Ziba
Mazari
zibamazarij@yahoo.com
200319475328460016466
200319475328460016466
No
Family Health Research Group, Health metrics Research center, Iranian Institute for Health Sciences Research, ACECR, Tehran, Iran.
Samira
Behboudi Gandevani
s.behboudi@hotmail.com
200319475328460016467
200319475328460016467
No
Reproductive Endocrinology Research centre, Research Institute for Endocrine Science, ShaheedBeheshti University of Medical Science, Tehran, Iran.
Mohsen
Naseri
naseri@shahed.ac.ir
200319475328460016468
200319475328460016468
No
Shahed Traditional Iranian Medicine Research Center, Tehran, Iran.