Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1395
10
1
gregorian
2017
1
1
31
1
online
1
fulltext
en
Serum mannan-binding lectin in patients with pulmonary tuberculosis: Its lack of a relationship to the disease and response to treatment
Infectious Disease
Infectious Disease
Original Research
Original Research
<p><strong>Background: </strong>Lectin pathway mediates complement activation, which is activated by many microorganisms. This study aimed at determining the serum levels of mannose-binding lectin (MBL) in patients with pulmonary tuberculosis, assessing its relationship to antiuberculosis treatment response, and comparing them with a control group.<br>
<strong> Methods:</strong> This cross-sectional study was conducted on patients with pulmonary tuberculosis during 2012 and 2013 in South West of Iran. PPD-ST-negative individuals were selected as controls from healthy relatives of patients. Serum MBL levels were measured using ELISA kit (Human MBL HK323, Hycultbiotech Company, Netherlands). All patients were followed- up for response to treatment. We applied Mann-Whitney and Fisher’s exact tests and used SPSS Version 17 software for statistical analysis.<br>
<strong>Results: </strong>The study included 62 patients as the case group and 63 noninfected TB patients as the control group. The MBL (ng/mL) in patients with pulmonary tuberculosis (median = 1012) was significantly (p= 0.037) higher than that of the control group (median= 296.2). No significant difference was found in the MBL level (ng/mL) between patients with response to antituberculosis treatment (median= 1012) and patients with treatment failure (median= 798.9) (p= 0.84).<br>
<strong> Conclusion:</strong> MBL may be involved in the pathogenesis of tuberculosis and in the low values that are protective against tuberculosis, and it seems that it has no effect on the antituberculosis treatment response.<br>
<br>
</p>
Tuberculosis, Mannose Binding Lectin, Immune System
379
382
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-2209-1&slc_lang=en&sid=1
Fatemeh
Ahmadi
dr_ahmadi031@yahoo.com
200319475328460034044
200319475328460034044
No
Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Ataallah
Ghadiri
ata.ghadiri@hotmail.fr
200319475328460034045
200319475328460034045
No
Immunology Department, School of Medicine, Ahvaz Jundishapur University of Medi-cal Sciences, Ahvaz, Iran.
Roohangiz
Nashibi
roohangizenashibi@yahoo.com
200319475328460034046
200319475328460034046
No
Immunology Department, School of Medicine, Ahvaz Jundishapur University of Medi-cal Sciences, Ahvaz, Iran.
Fatemeh
Roozbeh
fatemehroozbeh@gmail.com
200319475328460034047
200319475328460034047
Yes
Immunology Department, School of Medicine, Ahvaz Jundishapur University of Medi-cal Sciences, Ahvaz, Iran.
Reza
Alizadeh-Navaei
reza_nava@yahoo.com
200319475328460034048
200319475328460034048
No
Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran.