Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1394
10
1
gregorian
2016
1
1
30
1
online
1
fulltext
en
Visfatin level in patients with colorectal adenoma
Surgery
Surgery
Original Research
Original Research
<p dir="ltr" style="text-align: justify;"><strong>Background: </strong>Visfatin is an adipocytokine secreted by visceral adipose tissue. It has been shown that adipocytokines may contribute to the induction of carcinogens and progression of tumors. Previously, we found a significant increase in the visfatin serum level in colorectal cancer patients. Herein, we investigated if this cytokine increases in patients with colorectal adenoma as a precursor of colorectal cancer.</p>
<p dir="ltr" style="text-align: justify;"><strong> Methods</strong>: In this case-control analytic study, a total of 34 patients diagnosed with colorectal adenoma and 35 disease-free controls were included. Adenomas were also categorized based on their location within the colon. Visfatin serum levels were measured in all cases and controls using enzyme-linked immunosorbent assay kits. In order to compare visfatin levels between groups a two-tailed t-test was considered. Pearson correlation was also used to assess the relationship between visfatin levels and other measured variables.</p>
<p dir="ltr" style="text-align: justify;"><strong> Results</strong>: Patients included 18 male (53%) and 16 female (47%) with a mean±SD age of 48.3±10.96 years and controls were 18 male (51%) and 17 female (49%) with a mean±SD age of 51.6±12.52 years. There were no significant difference in terms of the visfatin level between the two groups (6.7±3.01 ng/ml for patients and 6.8±2.49 ng/ml for controls, p>0.05). Except for a significant correlation between the BMI and visfatin level (p=0.041), no other correlation was detected. We found no significant difference between the levels of visfatin in each location of adenoma comparing the healthy controls (p>0.05 in all comparisons). There was no statistical difference between the locations groups in terms of visfatin level as well (p>0.05).</p>
<p dir="ltr" style="text-align: justify;"><strong> Conclusion</strong>: Visfatin serum level does not significantly increase in patients with colorectal adenoma. Site of adenoma within the colon or rectum does not seem to play an important role in this regard as well.</p>
Colorectal adenoma, Visfatin, Adipocytokine, Colon, Rectum.
73
76
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-951&slc_lang=en&sid=1
Mohammad Sadegh
Fazeli
mhfazeli@yahoo.com
200319475328460020907
200319475328460020907
No
Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Reza
Keramati
dr_morezak@yahoo.com
200319475328460020908
200319475328460020908
Yes
Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran.
Azam
Rahimi
azamrahimi7878@yahoo.com
200319475328460020909
200319475328460020909
No
Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran.
Alireza
Kazemeini
alikazemeini@gmail.com
200319475328460020910
200319475328460020910
No
Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Mehdi
Banoei
mmbanoei@yahoo.com
200319475328460020911
200319475328460020911
No
Department of Critical Care Medicine, University of Calgary, Calgary, Canada
Habibollah
Dashti
shad_3070@yahoo.com
200319475328460020912
200319475328460020912
No
Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran.
Amir Reza
Fazeli
mhfazeli@yahoo.com
200319475328460020913
200319475328460020913
No
Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran.