Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1394
10
1
gregorian
2016
1
1
30
1
online
1
fulltext
en
Prevalence of hepatic steatosis and associated factors in Iranian patients with chronic hepatitis C
Gastroenterology and Liver Disease
Gastroenterology and Liver Disease
Original Research
Original Research
<p dir="ltr" style="text-align: justify;"><strong>Background: </strong>Hepatic steatosis is commonly observed in patients with chronic hepatitis C (CHC). Many studies indicate a relationship between steatosis and fibrosis progression. The aim of this study was to analyze the prevalence of hepatic steatosis and related factors in Iranian CHC patients.</p>
<p dir="ltr" style="text-align: justify;"><strong> Methods</strong>: One hundred and fifteen consecutive patients with CHC were enrolled which were treatment-naïve. The patients were divided into groups with and without steatosis according to the result of liver biopsy (58.3% and 41.7%, respectively). Demographic, histological, biochemical and virological factors were examined and compared in all patients.</p>
<p dir="ltr" style="text-align: justify;"><strong> Results</strong>: In terms of host factors, body mass index (BMI), triglyceride, fasting blood glucose (FBG), necroinflammatory activity and severity in fibrosis of CHC patients with steatosis was significantly higher than the patients without steatosis. Of viral factors, HCV viral load was not significantly altered in patients with steatosis. Moreover, HCV genotypes did not meet such association. Using multivariate regression analysis, parameters of BMI values, FBG level and stage of fibrosis were independently associated with steatosis.</p>
<p dir="ltr" style="text-align: justify;"><strong> Conclusion</strong>: Our data indicate that CHC patients are more susceptible to development of hepatic steatosis. Based on our results, grade of steatosis appears to be associated with hepatic fibrosis progression rate in CHC patients.</p>
Chronic hepatitis C, Steatosis, Fibrosis, Necroinflammatory activity.
85
92
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-956&slc_lang=en&sid=1
Vahdat
Poortahmasebi
poortahmasebi@razi.tums.ac.ir
200319475328460021047
200319475328460021047
No
Hepatitis B Molecular Laboratory, Department of Virology, School of Public Health, Tehran University of Medical Sciences, Teh-ran, Iran.
Mohammad Sajad
Emami Aleagha
sajad.emami@modares.ac.ir
200319475328460021048
200319475328460021048
No
Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Mehdi
Amiri
Mamiri@uwo.ca
200319475328460021049
200319475328460021049
No
Department of Cell Biology and Anatomy, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Mostafa
Qorbani
mqorbani1379@gmail.com
200319475328460021050
200319475328460021050
No
Department of Community Medicine, Alborz University of Medical Sciences, Karaj, Iran & Non-Communicable Disease Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad
Farahmand
m_farahmand@razi.tums.ac.ir
200319475328460021051
200319475328460021051
No
Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Hamid
Asayesh
asayeshpsy@gmail.com
200319475328460021052
200319475328460021052
No
Department of Medical Emergencies, Qom University of Medical Sciences, Qom, Iran.
Seyed Moayed
Alavian
alavian@thc.ir
200319475328460021053
200319475328460021053
Yes
Middle East Liver Diseases (MELD) Center, Tehran, Iran.