Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1395
10
1
gregorian
2017
1
1
31
1
online
1
fulltext
en
Roles of triglyceride and phosphate in atherosclerosis of diabetic hemodialysis patients
Vascular & Trauma Surgery
Vascular & Trauma Surgery
Original Research
Original Research
<p dir="ltr"><strong>Background: </strong>A growing number of patients with End-Stage Renal Disease (ESRD) are undergoing long-term hemodialysis (HD). HD needs a vascular access (VA) and complications of VA account for a sizable proportion of its costs. One of the important cardiovascular diseases (CVD) is atherosclerosis, which is a major cause of premature deaths in the world. So, it is essential to find the risk factors to treat them before they cause an obvious CVD.<br>
<strong> Methods: </strong>We analyzed data from 174 ESRD patients who were candidate for Arterio Venous Fistula (AVF) creation from April 2008 to March 2009 in Hasheminejad Kidney Center by convenient sampling. X-ray images were used and C 4.5 algorithm of data mining techniques revealed the roles of two risk factors for atherosclerosis of diabetic ESRD patients. Pearson coefficient was also used to measure the correlation between the parameters.<br>
<strong> Results: </strong>Diabetic patients had significantly more calcified arteries in their forearm X-ray than other patients (p<0.001). Occurrence of atherosclerotic CVD in diabetic HD patients has an adverse relation compared with the controlled levels of their plasma levels of Triglyceride (TG) and Phosphorus. We found an inverse effect of TG and phosphorus plasma levels on the atherosclerotic involvement of radial and ulnar arteries in diabetic HD patients. We observed that the prevalence of radial and ulnar arteries calcification in these patients is lower when they have higher plasma levels of TG and phosphorous.<br>
<strong> Conclusion:</strong> This study investigates the role of high plasma levels of TG and phosphorous in the development of atherosclerosis in diabetic HD patients. Although many studies showed that hypertriglyceridemia plays a promoting role in the development of CVD, our study also found an inverse effect of plasma levels of TG on the atherosclerotic involvement of radial and ulnar arteries in diabetic patients, and therefore our results support this suspicion that hypertriglyceridemia plays a significant role in developing atherosclerosis.<br>
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</p>
Image Mining, X-ray, Arterial Calcification, Atherosclerosis, Diabetes Mellitus, Triglyceride, Phosphorus, inverse effect
465
471
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1435-6&slc_lang=en&sid=1
Mohammad
Rezapour
mrezapour@srbiau.ac.ir
200319475328460034122
200319475328460034122
No
Department of Information Technology Management, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Elnaz
Payani
elnaz.pyn@gmail.com
200319475328460034123
200319475328460034123
No
Bamberg Clinic, Germany
Masoumeh
Taran
m.taran@mailfa.com
200319475328460034124
200319475328460034124
No
Applied Mathematics Institute for Advanced Studies in Basic Sciences (IASBS)
Ali
Rajabzadeh Ghatari
alirajabzadeh@modares.ac.ir
200319475328460034125
200319475328460034125
No
Tarbiat Modares University (TMU)
Morteza
Khavanin Zadeh
khavaninzadeh.m@iums.ac.ir
200319475328460034126
200319475328460034126
Yes
Iran University of Medical Sciences