Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1394
10
1
gregorian
2016
1
1
30
1
online
1
fulltext
en
Vascular endothelial growth factor expression and vascular densi-ty in oral squamous cell carcinoma (OSCC): A study on clinical and histopathologic significance
Original Research
Original Research
<p dir="ltr" style="text-align: justify"><strong>Background: </strong>New blood vessels formation is a critical step in tumor progression. Vascular density affects the clinical outcome and prognosis of malignant tumors. The aim of this study was to investigate the relation between the Vascular Endothelial Growth Factor (VEGF) expression and vascular density with the clinical and histopathologic features in oral squamous cell carcinoma (OSCC).</p>
<p dir="ltr" style="text-align: justify"><strong> Methods</strong>: In this retrospective study, 22 paraffin embedded block of well-differentiated OSCC were examined immunohistochemically for VEGF expression. Vascular density was determined by counting the blood vessels in 6 fields with 100 (HPF) on hematoxylin-eosin stained slides. The relation between the VEGF expression and vascular density with clinical and histopathologic features were analyzed by t-test, ANOVA, and Chi-square tests.</p>
<p dir="ltr" style="text-align: justify"><strong> Results</strong>: A significant relation between gender (P=0.06) and tumor size (p=0.05) with vascular density was obtained. The relation between VEGF expression and gender (p=0.41), age (p=0.35), lymph node involvement (p=0.38), tumor size (p=0.15) and tumor differentiation (p=0.34) was not significant. The relation between vascular density and age (p=0.55), lymph node involvement (p=0.20), and tumor differentiation (p=0.80) was not significant.</p>
<p dir="ltr" style="text-align: justify"><strong> Conclusion</strong>: Blood vessels formation relates to tumor size. Controlling the tumor size by manipulating the blood vessels formation may contribute to the inhibition of tumor progression in malignant tumors.</p>
Oral, Squamous Cell Carcinoma, Vascular Endothelial Growth Factor, Microvessel density.
401
406
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-990&slc_lang=en&sid=1
Noushin Jalayer
Naderi
jalayer@shahed.ac.ir
200319475328460022171
200319475328460022171
Yes
Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Shahed University, Tehran, Iran.
Farrokh
Tirgari
sam_varnaseri@yahoo.com
200319475328460022172
200319475328460022172
No
Pathology Department, Institute Cancer, Tehran University of Medical Sciences, Tehran, Iran. hosp_cancer@tums.ac.ir 3. DDS, Shahed University, Tehran, Iran.
Zahra
Keshavarz
sam_varnaseri@yahoo.com
200319475328460022173
200319475328460022173
No
Shahed University, Tehran, Iran.