Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1394
10
1
gregorian
2016
1
1
30
1
online
1
fulltext
en
A comparison of pattern of psychiatric symptoms in inpatients with bipolar disorder type one with & without methamphetamine use
Psychiatry
Psychiatry
Original Research
Original Research
<p style="text-align: justify;"><strong>Background: </strong>Iran is facing an outbreak of methamphetamine-induced disorders and frequent use of these substances in patients with bipolar disorder. Using or intoxication of methamphetamine in patients with bipolar I disorder may alter the patient's clinical profile; however there is limited studies about impact of methamphetamine on clinical manifestation of bipolar disorders. This study aimed to compare psychiatric symptoms in patients with bipolar I disorder with and without concomitant use of methamphetamine.</p>
<p style="text-align: justify;"><strong> Methods:</strong> In a cross-sectional study, psychiatric symptoms of bipolar I disorder in patients with (Meth+) and without (Meth-) methamphetamine use was evaluated. A number of 57 participants with Meth + and 50 subjects with Meth- were recruited. The clinical picture of bipolar disorder was investigated by Young Mania Rating Scale (YMRS), 17-item Hamilton Depressive Rating Scale (HDRS-17) and the Scale for Assessment of Positive Symptoms (SAPS). Statistical comparisons were performed using the T-test for independent samples and Mann-Whitney test.</p>
<p style="text-align: justify;"><strong> Results:</strong> There was no statistically significant difference between two groups regarding age, duration of illness and hospitalizations. However, male participants were significantly higher in Meth+ group than in Meth- one (p<0.001). The mean (± SD) scores in the two groups of Meth+ and Meth- for YMRS, HDRS, and SAPS were 31.3 (±1.3) and 34.0 (±1.2), 13.7 (±0.7) and 13.5±(0.5), and 50.0 (±1.9) and 48.0 (±2.1), respectively, which were not statistically significant (p<0.05).</p>
<p style="text-align: justify;"><strong> Conclusion:</strong> There was no significant difference in the overall clinical manifestation of bipolar I disorder in patients with and without methamphetamine use. However, in some symptomatology domains, there were some differences between the two groups.</p>
Bipolar one disorder, Methamphetamine, Manic episode, Psychosis.
871
879
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-1054&slc_lang=en&sid=1
Elham
Gouran Ourimi
elhamgouran@gmail.com
200319475328460024553
200319475328460024553
No
Department of Psychiatry, Iran University of Medical Science, Tehran, Iran.
Amir
Shabani
shabani.a@iums.ac.ir
200319475328460024554
200319475328460024554
Yes
Bipolar Disorders Research Group, Iran University of Medical Sciences, Tehran, Iran.
Kaveh
Alavi
kavehalavi@yahoo.com
200319475328460024555
200319475328460024555
No
Mental Health Research Center, Bipolar Disorders Research Group, Iran University of Medical Sciences, Tehran, Iran.
Mohammad Reza
Najarzadegan
najarzadegan2010@gmail.com
200319475328460024556
200319475328460024556
No
Department of Psychiatry, Iran University of Medical Science, Tehran, Iran.
Fatemehsadat
Mirfazeli
f.sm6876@gmail.com
200319475328460024557
200319475328460024557
No
Department of Psychiatry, Iran University of Medical Science, Tehran, Iran.