Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1394
10
1
gregorian
2016
1
1
30
1
online
1
fulltext
en
Resistance of Shigella strains to extended-spectrum cephalosporins in Isfahan province
Infectious Disease
Infectious Disease
Original Research
Original Research
<p style="text-align: justify"><strong>Background: </strong>The aim of this study was to determine the serotypes and antimicrobial susceptibility of Shigella spp. in Isfahan, (Iran) from 2010 to 2015.</p>
<p style="text-align: justify"><strong> Methods:</strong> This retrospective study was conducted on Shigella isolates in four tertiary care hospitals. The process of bacterial isolation and determination of susceptibility was performed by standard microbiological guidelines. The patients were categorized into three age groups of under 5, 5-15 and over 15 years.</p>
<p style="text-align: justify"><strong> Results:</strong> Among 45 isolates, S. sonnei (63.6%) was the predominant species, followed by S. flexneri (34.1%), and S. dysenteriae (2.3%). Substantial resistance to ampicillin, trimethoprim- sulfamethoxazole, ceftriaxone, cefotaxime, and cefixime was observed. Over 94% of the isolates were sensitive to ciprofloxacin. Susceptibility of isolates was similar between all age groups.</p>
<p style="text-align: justify"><strong> Conclusion:</strong> Significant resistance to third generation cephalosporins precludes the use of these agents for empirical treatment of shigellosis in our population. Ciprofloxacin is an appropriate option; however, susceptibility tests should be performed before prescription.</p>
<p></p>
Shigellosis, Susceptibility, Ciprofloxacin, Third Generation Cephalosporin, Iran.
932
936
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-1061&slc_lang=en&sid=1
Nasser
Mostafavi
n_mostafavy@med.mui.ac.ir
200319475328460024941
200319475328460024941
Yes
Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Moein
Bighamian
mb.baran1920@yahoo.com
200319475328460024942
200319475328460024942
No
Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non Communicable Disease, Isfa-han University of Medical Sciences, Isfahan, Iran.
Sina
Mobasherizade
mobasherizadeh@gmail.com
200319475328460024943
200319475328460024943
No
Nosocomial Infections Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Roya
Kelishadi
roya.kelishadi@gmail.com
200319475328460024944
200319475328460024944
No
Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non Communicable Disease, Isfa-han University of Medical Sciences, Isfahan, Iran.