Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1396
11
1
gregorian
2018
2
1
32
1
online
1
fulltext
en
Effects of vitamin D optimization on quality of life of patients with fibromyalgia: A randomized controlled trial
Rheumatology
Rheumatology
Original Research: Clinical Science
Original Research: Clinical Science
<p><strong>Background: </strong>Numerous studies have been conducted to evaluate the frequency of hypovitaminosis D in patients with fibromyalgia syndrome (FMS) and its association with FMS symptoms. This study aimed at assessing the effect of hypovitaminosis D on the symptoms and quality of life of patients with fibromyalgia.<br>
<strong>Methods:</strong> A total of 74 FMS patients with hypovitaminosis D were randomly assigned into group A (Trazodone 25 mg at bedtime + vitamin D 50 000 IU weekly) and group B (Trazodone 25 mg at bedtime + placebo). Serum vitamin D level, Widespread Pain Index (WPI), Fibromyalgia Impact Questionnaire (FIQ), Pittsburgh Sleep Quality Index (PSQI), and Short Form Health Survey (SF-36) were used at the beginning of the treatment and 4 and 8 weeks post treatment.<br>
<strong>Results: </strong>Significant improvements were observed in WPI, FIQ, and PSQI scores in both groups. Moreover, combination of vitamin D and Trazodone resulted in significant improvement of SF-36 scores compared to Trazodone therapy. Improvement in pain-related indices including the WPI and the physical component score (PCS) fraction of SF-36 was more noticeable in vitamin D/Trazodone combination therapy.<br>
<strong> Conclusion:</strong> This study suggests that vitamin D supplementation has significant therapeutic benefits in the management of FMS, especially in pain reduction of patients with fibromyalgia. According to our results, a combination of vitamin D supplements and a conventional antidepressant, when given to vitamin D-deficient fibromyalgia patients, could significantly improve both physical and psychological symptoms.<br>
</p>
Fibromyalgia syndrome, Vitamin D, Pain, Quality of life
167
172
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-2649-2&slc_lang=en&sid=1
Alireza
Mirzaei
mirzaeialireza26@gmail.com
200319475328460037503
200319475328460037503
No
Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.
Mozhdeh
Zabihiyeganeh
Mozhdehzabihi@gmail.com
200319475328460037504
200319475328460037504
Yes
Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.
Seyed Adel
Jahed
adeljahed@yahoo.com
200319475328460037505
200319475328460037505
No
Research Center for Prevention of Cardiovascular Diseases, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.
Elnaz
Khiabani
khiabani_e@yahoo.com
200319475328460037506
200319475328460037506
No
Hematology- Oncology Department, Emam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Marzieh
Nojomi
mnojomi@gmail.com
200319475328460037507
200319475328460037507
No
Preventive Medicine & Public Health Research Center, Department of Community Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Salman
Ghaffari
orthosalman@yahoo.com
200319475328460037508
200319475328460037508
No
Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.