Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1397
11
1
gregorian
2019
2
1
33
1
online
1
fulltext
en
The role of IGF-1 in obesity, cardiovascular disease, and cancer
Nutrition
Nutrition
Review Article
Review Article
<strong>Background: </strong>Insulin-like growth factor1 (IGF1) is a polypeptide that structurally is similar to human pro-insulin, one of the factors that is altered in obesity and many related diseases, hence a large body of research devoted to evaluate it.<br>
<strong>Methods:</strong> In this mini-review, we briefly explain the role of IGF1 in different conditions, including obesity, cardiovascular disease, and cancer through the results of review and original articles in both animal and human studies.<br>
<strong>Results: </strong>The short-term metabolic effect of IGF-1 is insulin-like, and its long-term effect is growth factor-like. IGF1 has different roles in the initiation and progression of different diseases, because in some cases, the anti-apoptotic effect, can help cell survival while in others, it may lead to cancer or increment of adipocytes.<br>
<strong> Conclusion:</strong> It is highly recommended to consider the different impacts of IGF1 in health and diseases prevention in future studies and interventions.<br>
IGF1, Obesity, Cardiovascular disease, Cancer, Apoptosis
342
345
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-3712-1&slc_lang=en&sid=1
Nazanin
AsghariHanjani
nazaninhanjani_1990@yahoo.com
200319475328460062640
200319475328460062640
No
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
Mohammadreza
Vafa
vafa.m@iums.ac.ir
200319475328460062641
200319475328460062641
Yes
Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran