Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1390
11
1
gregorian
2012
2
1
26
1
online
1
fulltext
en
Mast cells density in fibrotic capsule of enchondroma and well-differentiated chondrosarcoma: a method for histopathologic differentiation
Original Research
Original Research
<p> <strong>Background:</strong> An enchondroma is a benign and a well-differentiated chondrosarcoma is an invasive chondroid tumor with high recurrence potential. In spite of biologic differences, these two tumors have very similar histopathologic appearance. It has been shown that the biologic nature of the connective tissue around benign and malignant tumors varies in the number of mast cells. The aim of this study was to study the histopathologic distinction of enchondroma and well-differentiated chondrosarcoma using the density of the mast cells in fibrotic capsule.</p><p> <strong>Methods:</strong> Twelve enchondroma and 15 well-differentiated chondrosarcoma were collected from Pathology department of Cancer Institute and Central Pathology department of Imam Khomeini Hospital in Tehran. 3 micron paraffin embedded tissue sections were stained by toluidine blue for mast cells counting. Mast cells were counted in fibrous capsule of all cases. Mast cells counts were accomplished in 10 high power fields .The average number of mast cells in 10HPF was determined as an index for each lesion. Mann-Whitney U test was used for statistical analysis.</p><p> <strong>Results:</strong> Mean index in enchondroma and well-differentiated chondrosarcoma groups were 0.1±0.12 and 0.31±0.33 respectively, showing a significant difference between number of mast cells in the fibrotic capsule in these two lesions (p=0.028). Comparison of the corresponding points in ROC curve, showed a cut-off point = 0.15, with positive predictive value of 61%, negative predictive value 71%, specificity of 33.3% and sensitivity of 66.7%, (p=0.025).</p><p> <strong>Conclusion:</strong> Average density of the mast cells in the surrounding fibrotic capsules of enchondroma and well-differentiated chondrosarcoma along with other criterions, could be a beneficial factor for histologically differentiation between these two lesions.</p>
Enchondroma, Well-differentiated Chondrosarcoma, Mast cell, Toluidine blue staining.
1
6
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-290&slc_lang=en&sid=1
Noushin
Jalayer Naderi
noushin_jly85@yahoo.com
20031947532846007500
20031947532846007500
Yes
Oral and Maxillofacial Pathology Dept, Faculty of Dentistry, Shahed University. Tehran, Iran.
Shams
Shariat Tarabghan
20031947532846007501
20031947532846007501
No
Pathology Dept, Institute Cancer, Tehran, Iran.
Mohsen
Merati
mohsenmerati@gmail.com
20031947532846007502
20031947532846007502
No
Dental researches center, Faculty of Dentistry, Mashhad University of Medical sciences, Mashhad, Iran.
Mahdi
Ashouri
m_ashouri86@yahoo.com
20031947532846007503
20031947532846007503
No
Ali
Majidi
alimajidi2008a@yahoo.com
20031947532846007504
20031947532846007504
No
Shahed University, Tehran, Iran.
Mohammad Javad
Kharazi Fard
mj_khf@yahoo.com
20031947532846007505
20031947532846007505
No
Dental Research Center. Tehran University of Medical Sciences, Tehran, Iran.